・査読付き論文
・総説
・著書
・招待講演
・医療講演会
査読付き論文
1.
Tomita H*, Ishiguro S, Abe T, Tamai M, Increased
expression of low-affinity NGF receptor in rat retinal Muller cells after
ischemia and reperfusion, Cell Struct Funct, 23(4), 201-7, 1998
2.
Abe T, Tomita H, Tamai M, Gene
expression of the phosducin-like protein in the retina, Ophthalmic Res, 30(2),
74-83, 1998
3.
Tomita H, Ishiguro S*, Abe T, Tamai M, Administration
of nerve growth factor, brain-derived neurotrophic factor and insulin-like
growth factor-II protects phosphate-activated glutaminase in the ischemic and
reperfused rat retinas, Tohoku J Exp Med, 187(3), 227-36, 1999
4.
Kobayashi
N, Ishiguro S, Tomita H*,
Nishikawa S, Tamai M, Changes of GABA metabolic enzymes in acute retinal
ischemia, Exp Eye Res, 69(1), 91-6, 1999
5.
Abe T*,
Yoshida M, Tomita H, Kano T,
Nakagawa Y, Sato M, Wada Y, Fuse N, Yamada T, Tamai M, Functional analysis
after auto iris pigment epithelial cell transplantation in patients with
age-related macular degeneration, Tohoku J Exp Med, 189(4), 295-305, 1999
6.
Abe T*, Tomita H, Ohashi T, Yamada K,
Takeda Y, Akaishi K, Yoshida M, Sato M, Tamai M, Characterization of iris
pigment epithelial cell for auto cell transplantation, Cell Transplant, 8(5),
501-10, 1999
7.
Abe T*,
Takeda Y, Yamada K, Akaishi K, Tomita
H, Sato M, Tamai M, Cytokine gene expression after subretinal
transplantation, Tohoku J Exp Med, 189(3), 179-89, 1999
8.
Tomita H*, Abe T, Tamai M, Ceramide-induced cell death
in cultured rat retinal pigment epithelial cells, Tohoku J Exp Med, 190(3),
223-9, 2000
9.
Nishiyama
T, Nishikawa S*, Tomita H,
Tamai M, Muller cells in the preconditioned retinal ischemic injury rat, Tohoku
J Exp Med, 191(4), 221-232, 2000
10. Abe T*, Yoshida M, Tomita H, Kano T, Sato M, Wada Y, Fuse N, Yamada T, Tamai M,
Auto iris pigment epithelial cell transplantation in patients with age-related
macular degeneration: short-term results, Tohoku J Exp Med, 191(1), 7-20, 2000
11. Abe T*, Tomita
H, Kano T, Yoshida M, Ohashi T, Nakamura Y, Nishikawa S, Tamai M,
Autologous iris pigment epithelial cell transplantation in monkey subretinal
region, Curr Eye Res, 20(4), 268-75, 2000.
12. Yokota T*, Igarashi K, Uchihara T, Jishage Ki, Tomita H, Inaba A, Li Y, Arita
M, Suzuki H, Mizusawa H, Arai H, Delayed-onset ataxia in mice lacking α-tocopherol
transfer protein: Model for neuronal degeneration caused by chronic oxidative
stress, Proc Natl Acad Sci U S A, 98(26), 15185-15190, 2001
13. Sakuragi M, Tomita H*, Abe T, Tamai M, Changes of phagocytic capacity in
basic fibroblast growth factor-transfected iris pigment epithelial cells in
rats, Curr Eye Res, 23(3), 185-91, 2001 (IF: 2.238)
14. Yamaguchi K*, Tomita H, Sugano E, Nakazawa T, Tamai M, Mitogen-activated
protein kinase inhibitor, PD98059, inhibits rat retinal pigment epithelial cell
replication by cell cycle arrest, Jpn J Ophthalmol, 46(6), 634-9, 2002
15. Tomita
H*, Nakazawa T, Sugano
E, Abe T, Tamai M, Nipradilol inhibits apoptosis by preventing the activation
of caspase-3 via S-nitrosylation and the cGMP-dependent pathway, Eur J
Pharmacol, 452(3), 263-8, 2002
16. Nakazawa T*, Tomita H, Yamaguchi K, Sato Y, Shimura M, Kuwahara S, Tamai
M, Neuroprotective effect of nipradilol on axotomized rat retinal ganglion
cells, Curr Eye Res, 24(2), 114-22, 2002
17. Kano T, Abe T*, Tomita H, Sakata T, Ishiguro S, Tamai M, Protective effect
against ischemia and light damage of iris pigment epithelial cells transfected
with the BDNF gene, Invest Ophthalmol Vis Sci, 43(12), 3744-53, 2002
18. Endo S, Tomita
H*, Ishiguro S, Tamai M, Effect of betaxolol on aspartate aminotransferase
activity in hypoxic rat retina in vitro, Jpn J Pharmacol (Journal of
Pharmacological Sciences), 90(2), 121-4, 2002
19. Akiyama H, Nakazawa T*, Shimura M, Tomita H, Tamai M, Presence of
mitogen-activated protein kinase in retinal Muller cells and its neuroprotective
effect ischemia-reperfusion injury, Neuroreport, 13(16), 2103-7, 2002
20. Yasuda K, Shimura M*, Nakazawa T, Sato H, Tomita H, Sugano E, Tamai M,
Expression and functional properties of unique inward rectifier K+ channel
Kir7.1 in the porcine iris and retinal pigment epithelium, Curr Eye Res, 27(5),
279-87, 2003
21. Sugano E, Tomita
H*, Abe T, Yamashita A, Tamai M, Comparative study of cathepsins D and
S in rat IPE and RPE cells, Exp Eye Res, 77(2), 203-9, 2003
22. Nakazawa T, Shimura M*, Tomita H, Akiyama H, Yoshioka Y, Kudou H, Tamai M, Intrinsic
activation of PI3K/Akt signaling pathway and its neuroprotective effect against
retinal injury, Curr Eye Res, 26(1), 55-63, 2003
23. Morita M, Ohneda O, Yamashita T, Takahashi S,
Suzuki N, Nakajima O, Kawauchi S, Ema M, Shibahara S, Udono T, Tomita K, Tamai M, Sogawa K,
Yamamoto M, Fujii-Kuriyama Y*, HLF/HIF-2alpha is a key factor in retinopathy of
prematurity in association with erythropoietin, EMBO J, 22(5), 1134-46, 2003
24. Ito A, Yamaguchi K*, Tomita H, Suzuki T, Onogawa T, Sato T, Mizutamari H,
Mikkaichi T, Nishio T, Unno M, Sasano H, Abe T, Tamai M, Distribution of rat
organic anion transporting polypeptide-E (oatp-E) in the rat eye, Invest
Ophthalmol Vis Sci, 44(11), 4877-84, 2003
25. Aikawa H, Tomita
H*, Ishiguro S, Nishikawa S, Sugano E, Tamai M, Increased expression of
glutamate binding protein mRNA in rat retina after ischemia-reperfusion injury,
Tohoku J Exp Med, 199(1), 25-33, 2003
26. Abe T*, Yoshioka Y, Tomita H, Saigo Y, Udono T, Shibahara S, Tamai M, Transgenic
rd mice harboring axokine gene by Rpe65 gene promoter does not rescue
photoreceptor degeneration, Adv Exp Med Biol, 533, 403-6, 2003
27. Saigo Y, Abe T*, Hojo M, Tomita H, Sugano E, Tamai M, Transplantation of transduced
retinal pigment epithelium in rats, Invest Ophthalmol Vis Sci, 45(6),
1996-2004, 2004
28. Hojo M, Abe T*, Sugano E, Yoshioka Y, Saigo Y, Tomita H, Wakusawa R, Tamai M,
Photoreceptor protection by iris pigment epithelial transplantation transduced
with AAV-mediated brain-derived neurotrophic factor gene, Invest Ophthalmol Vis
Sci, 45(10), 3721-6, 2004
29. Zhou X, Li F, Kong L, Tomita H, Li C, Cao W*, Involvement of inflammation,
degradation, and apoptosis in a mouse model of glaucoma, J Biol Chem, 280(35),
31240-8, 2005
30. Tomita
H, Kotake Y, Anderson RE*,
Mechanism of protection from light-induced retinal degeneration by the
synthetic antioxidant phenyl-N-tert-butylnitrone, Invest Ophthalmol Vis Sci,
46(2), 427-34, 2005
31. Sugano E, Tomita
H*, Ishiguro S, Abe T, Tamai M, Establishment of effective methods for
transducing genes into iris pigment epithelial cells by using adeno-associated
virus type 2, Invest Ophthalmol Vis Sci, 46(9), 3341-8, 2005
32. Sato H*, Tomita
H, Nakazawa T, Wakana S, Tamai M, Deleted in polyposis 1-like 1 gene
(Dp1l1): a novel gene richly expressed in retinal ganglion cells, Invest
Ophthalmol Vis Sci, 46(3), 791-6, 2005
33. Yoshioka Y, Abe T*, Wakusawa R, Moriya T,
Mochizuki S, Saigo Y, Saito T, Murata H, Tokita Y, Iseya T, Sugano E, Tomita H, Sagara Y, Tamai M,
Recombinant AAV-transduced iris pigment epithelial cell transplantation may
transfer vector to native RPE but suppress systemic dissemination, Invest
Ophthalmol Vis Sci, 47(2), 745-52, 2006
34. Sugano E, Tomita
H*, Ishiguro S, Isago H, Tamai M, Nitric oxide-induced accumulation of
lipofuscin-like materials is caused by inhibition of cathepsin S, Curr Eye Res,
31(7-8), 607-16, 2006
35. Sato Y, Tomita
H*, Sugano E, Isago H, Yoshida M, Tamai M, Evaluation of indocyanine
green toxicity to rat retinas, Ophthalmologica, 220(3), 153-8, 2006
36. Motonami K, Watanabe T, Deguchi J, Fukushima T,
Tomita H, Sugano E, Sato M,
Kurino H*, Tamai M, Koyanagi M, Evaluation of electrical stimulus current
applied to retina cells for retinal prosthesis, Japanese Journal of Applied
Physics, 45(4 B), 3784-3788, 2006
37. Kunikata H*, Tomita H, Murata H, Sagara Y, Sato H, Wada Y, Fuse N,
Nakagawa Y, Abe T, Tamai M, Hypothermia protects cultured human retinal pigment
epithelial cells against trypan blue toxicity, Ophthalmologica, 220(2), 114-7,
2006
38. Zhou X, Li F, Ge J, Sarkisian Sr, Jr., Tomita H, Zaharia A, Chodosh J,
Cao W*, Retinal ganglion cell protection by 17-beta-estradiol in a mouse model
of inherited glaucoma, Dev Neurobiol, 67(5), 603-16, 2007
39. Watanabe T, Kobayashi R, Komiya K, Fukushima T,
Tomita H, Sugano E, Kurino H,
Tanaka T*, Tamai M, Koyanagi M, Evaluation of platinum-black stimulus electrode
array for electrical stimulation of retinal cells in retinal prosthesis system,
Japanese Journal of Applied Physics, 46(4B), 2785-2791, 2007
40. Tomita
H*, Sugano E, Yawo H,
Ishizuka T, Isago H, Narikawa S, Kugler S, Tamai M, Restoration of visual
response in aged dystrophic RCS rats using AAV-mediated channelopsin-2 gene
transfer, Invest Ophthalmol Vis Sci, 48(8), 3821-6, 2007
41. Ozaki T, Tomita
H, Tamai M, Ishiguro S*, Characteristics of mitochondrial calpains, J
Biochem, 142(3), 365-76, 2007
42. Li G, Anderson RE*, Tomita H, Adler R, Liu X, Zack DJ, Rajala RV, Nonredundant
role of Akt2 for neuroprotection of rod photoreceptor cells from light-induced
cell death, J Neurosci, 27(1), 203-11, 2007
43. Kunikata H, Tomita H, Abe T, Murata H, Sagara Y, Sato H, Wada Y, Fuse N,
Nakagawa Y, Tamai M, Nishida K*, Hypothermia protects cultured human retinal
pigment epithelial cells against indocyanine green toxicity, J Ocul Pharmacol
Ther, 23(1), 35-9, 2007
44. Yoshida H, Tomita
H*, Sugano E, Isago H, Ishiguro S, Tamai M, BDNF increases the
phagocytic activity in cultured iris pigment epithelial cells, Cell Struct
Funct, 33(1), 21-6, 2008
45. Komiya K, Kobayashi R, Kobayashi T, Sato K, Fukushima
T, Tomita H, Kurino H, Tanaka
T, Tamai M, Koyanagi M*, Power supply system using electromagnetic induction
for three-dimensionally stacked retinal prosthesis chip, Japanese Journal of
Applied Physics, 47, 3244-3247, 2008
46. Wang H, Sugiyama Y, Hikima T, Sugano E, Tomita H, Takahashi T, Ishizuka
T, Yawo H*, Molecular determinants differentiating photocurrent properties of
two channelrhodopsins from Chlamydomonas, J Biol Chem, 284(9), 5685-96, 2009
47. Tomita
H*, Sugano E, Fukazawa Y,
Isago H, Sugiyama Y, Hiroi T, Ishizuka T, Mushiake H, Kato M, Hirabayashi M,
Shigemoto R, Yawo H, Tamai M, Visual properties of transgenic rats harboring
the channelrhodopsin-2 gene regulated by the thy-1.2 promoter, PLoS One, 4(11),
e7679, 2009
48. Tomita
H*, Sugano E, Isago H, Tamai
M, Channelrhodopsins provide a breakthrough insight into strategies for curing
blindness. J Genet, 88(4), 409-15. 2009
49. Tomita
H*, Sugano E, Isago H,
Hiroi T, Wang Z, Ohta E, Tamai M, Channelrhodopsin-2 gene transduced into
retinal ganglion cells restores functional vision in genetically blind rats,
Exp Eye Res, 90(3), 429-36, 2010
50. Semo M, Gias C, Ahmado A, Sugano E, Allen AE,
Lawrence JM, Tomita H, Coffey
PJ, Vugler AA*, Dissecting a role for melanopsin in behavioural light aversion
reveals a response independent of conventional photoreception, PLoS One, 5(11),
e15009, 2010
51. Wang Z, Sugano E, Isago H, Hiroi T, Tamai M, Tomita H*, Differentiation of
neuronal cells from NIH/3T3 fibroblasts under defined conditions, Dev Growth
Differ, 53(3), 357-65, 2011
52. Sugano E, Isago H, Wang Z, Murayama N, Tamai M,
Tomita H*, Immune responses
to adeno-associated virus type 2 encoding channelrhodopsin-2 in a genetically
blind rat model for gene therapy, Gene Ther, 18(3), 266-74, 2011
53. Wang Z, Sugano E, Isago H, Murayama N, Tamai M,
Tomita H*, Notch signaling
pathway regulates proliferation and differentiation of immortalized Muller
cells under hypoxic conditions in vitro, Neuroscience, 214, 171-80, 2012
54. Ozaki T*, Nakazawa M, Yamashita T, Sorimachi H,
Hata S, Tomita H, Isago H,
Baba A, Ishiguro S, Intravitreal injection or topical eye-drop application of a
mu-calpain C2L domain peptide protects against photoreceptor cell death in
Royal College of Surgeons' rats, a model of retinitis pigmentosa, Biochim
Biophys Acta, 1822(11), 1783-95, 2012
55. Isago H, Sugano E, Wang Z, Murayama N, Koyanagi
E, Tamai M, Tomita H*,
Age-dependent differences in recovered visual responses in Royal College of
Surgeons rats transduced with the Channelrhodopsin-2 gene, J Mol Neurosci,
46(2), 393-400, 2012
56. Sugano E, Murayama N, Takahashi M, Tabata K,
Tamai M, Tomita H*, Essential
role of thioredoxin 2 in mitigating oxidative stress in retinal epithelial
cells, J Ophthalmol, 2013, 185825, 2013
57. Sugano E, Isago H, Murayama N, Tamai M, Tomita H*, Different anti-oxidant
effects of thioredoxin 1 and thioredoxin 2 in retinal epithelial cells, Cell
Struct Funct, 38(1), 81-8, 2013
58. Ozaki T*, Nakazawa M, Yamashita T, Tomita H,
Ebina Y, Ishiguro S, Decrease of ATP by mitochondrial m-calpain inhibitory
peptide in the rat retinas, Cell Struct Funct, 38(2), 207-23, 2013
59. Ozaki T, Ishiguro S, Hirano S, Baba A,
Yamashita T, Tomita H,
Nakazawa M*, Inhibitory peptide of mitochondrial mu-calpain protects against
photoreceptor degeneration in rhodopsin transgenic S334ter and P23H rats, PLoS
One, 8(8), e71650, 2013
60. Osawa S, Iwasaki M, Hosaka R, Matsuzaka Y, Tomita H, Ishizuka T, Sugano E,
Okumura E, Yawo H, Nakasato N, Tominaga T, Mushiake H*, Optogenetically induced
seizure and the longitudinal hippocampal network dynamics, PLoS One, 8(4),
e60928, 2013
61. Kigure C, Naganuma H, Sasaki Y, Kino H, Tomita H, Tanaka T*, Fabrication
and In vivo Evaluation of Poly(3,4-ethylenedioxythiophene) Stimulus Electrodes
for Fully Implantable Retinal Prosthesis, Japanese Journal of Applied Physics,
52(4S), 4CL03-1-04CL03-5, 2013
62. Isago H, Sugano E, Murayama N, Tamai M, Tomita H*, Establishment of
monocular-limited photoreceptor degeneration models in rabbits, BMC Ophthalmol,
13, 19, 2013
63.
Tomita H*,
Sugano E, Murayama N, Ozaki T, Nishiyama F, Tabata K, Takahashi M, Saito T,
Tamai M, Restoration of the majority of the visual spectrum by using modified
Volvox channelrhodopsin-1, Mol Ther, 22(8), 1434-40, 2014
64. Hososhima S, Yuasa H, Ishizuka T, Hoque Mr,
Yamashita T, Yamanaka A, Sugano E, Tomita
H, Yawo H*, Near-infrared (NIR) up-conversion optogenetics, Sci Rep, 5,
16533, 2015
65. Tomiyama Y, Fujita K, Nishiguchi KM*, Tokashiki
N, Daigaku R, Tabata K, Sugano E, Tomita
H, Nakazawa T, Measurement of Electroretinograms and Visually Evoked
Potentials in Awake Moving Mice, PLoS One, 11(6), e0156927, 2016
66.
Tomita H,
Tabata K, Takahashi M, Nishiyama F, Sugano E*, Light induces translocation of
NF-kappaB p65 to the mitochondria and suppresses expression of cytochrome c
oxidase subunit III (COX III) in the rat retina, Biochem Biophys Res Commun,
473(4), 1013-8, 2016
67. Sugano E, Tabata K, Takahashi M, Nishiyama F,
Shimizu H, Sato M, Tamai M, Tomita H*,
Local and systemic responses following intravitreous injection of AAV2-encoded
modified Volvox channelrhodopsin-1 in a genetically blind rat model, Gene Ther,
23(2), 158-66, 2016
69. Ozaki T*, Yamashita T, Tomita H, Sugano E, Ishiguro SI, The protection of rat retinal ganglion cells from
ischemia/reperfusion injury by the inhibitory peptide of mitochondrial
μ-calpain, Biochem Biophys Res Commun, 478(4), 1700-5, 2016
71. You M, Yamane T, Tomita H, Sugano E, Akashi T*, A novel rat head gaze
determination system based on optomotor responses, PLoS One, 12(4), e0176633,
2017
72. Li H, Xu C, Li Q, Gao X, Sugano E, Tomita H, Yang L, Shi S*,
Thioredoxin 2 offers protection against mitochondrial oxidative stress and hypertrophy
induced by hyperglycemia in H9c2, Int J Mol Sci, 18(9), E1958, 2017
74. Fukuda T, Ishizawa Y, Donai K, Sugano E, Tomita H*, The poly-cistronic
expression of four transcriptional factors (CRX, RAX, NEURO-D, OTX2) in
fibroblasts via retro- or lentivirus causes partial reprogramming into
photoreceptor cells, Cell Biol Int, 42(5), 608-614, 2018
77. Iwamoto T, Ishiyama E, Ishida K, Yamashita T, Tomita
H, Ozaki T*. Presence of calpain-5 in mitochondria, Biochem Biophys Res
Commun, 504(2), 454-459, 2018
78. Shibuya H, Watanabe R, Maeno A, Ichimura K,
Tamura M, Wakana S, Shiroishi T, Ohba K, Takeda K, Tomita H,
Shibahara S, Yamamoto H, Melanocytes contribute to the vasculature of the
choroid, Genes Genet Syst. 93(2), 51-58.2018
82. Fukuda T, Gouko R, Eitsuka T, Suzuki R,
Takahashi K, Nakagawa K, Sugano E, Tomita H, Kiyono T. Human-Derived Corneal
Epithelial Cells Expressing Cell Cycle Regulators as a New Resource for in
vitro Ocular Toxicity Testing. Front Genet. 10, 587, 2019
83. Utsumi S, Sakamoto K, Yamashita T, Tomita
H, Sugano E, Ishida K, Ishiyama E, Ozaki T, Presence of ES1 homolog in
the mitochondrial intermembrane space of porcine retinal cells, Biochem Biophys
Res Commun. 524(3), 542-548, 2020
85. Ozaki T, Utsumi S, Iwamoto T, Tanaka M, Tomita H,
Sugano E, Ishiyama E, Ishida K. Data on mitochondrial ultrastructure of
photoreceptors in pig, rabbit, and mouse retinas, Data Brief. 30, 105544, 2020
87.
Chukai Y, Iwamoto T, Itoh K, Tomita H, Ozaki T, Characterization
of mitochondrial calpain-5. Biochim Biophys Acta Mol
Cell Res. 1868(5):118989, 2021
総説
1.
富田浩史*, 阿部俊明, 玉井信.眼 網膜の再生機構と先天性網膜疾患治療への応用, 【再生医学】, 臨床科学, 34(9): 1276-1282. (1998)
2.
阿部俊明, 玉井信, 西郷陽子, 北条昌芳, 鹿野哲也, 富田浩史, 吉田まどか, 吉岡由紀, 鵜殿徹男, 山下あさひ, 桜木素子, 和田裕子, 佐藤肇, 板橋俊隆, 相良淑子, 菅野江里子, 高橋真弓, 中村幸江, 大和雅之, 岡野光夫, 柴原茂樹, 菊池孝信. 「眼の再生医学 色素上皮細胞を利用した網膜再生医療の可能性」日本眼科学会雑誌, 106(12), 778-804. (2002)
3.
富田浩史*. 網膜移植,【眼組織移植と免疫】, NEW MOOK 眼科, (3): 78-87. (2002)
4.
富田浩史*. 緑内障とニューロプロテクション. 臨床眼科, 56(11): 1523-1528. (2002)
5.
富田浩史*. 網膜虚血と細胞死, "眼内血管病変の病態研究と治療法の発達" 日本眼科学会雑誌, 106(臨増): 76. 180-184. (2002)
6.
Tomita
H*, Sugano E, Abe T,
Yamashita A, Tamai M. Comparative study of cathepsin D and S in rat IPE and RPE
cells. Advances in Experimental Medicine and Biology. 533: 343-346. 2003.
7.
冨田浩史*, 玉井信. 網膜組織再生治療へのアプローチ,【細胞治療とDDS】, Drug Delivery System, 18(2): 95-103. (2003)
8.
富田浩史*, 小柳光正, 玉井信. 1チップ型人工網膜, 視機能再生工学 人工視覚【眼科における最新医工学】, 臨床眼科, 59(11): 106-110. (2005)
9.
富田浩史*. 網膜疾患における人工網膜の展望. 臨床眼科, 60(4): 593. (2006)
10. 小柳光正, 田中徹, 富田浩史. 人工網膜の実現へ 眼球埋め込み用人工網膜チップ, 【視覚メカニズムから探る脳の世界】. Biophilia, 2(2): 32-37. (2006)
11. 富田浩史*. 眼科医の手引 人工網膜は実現するか?"
日本の眼科, 77(3): 283-284. (2006)
12. 富田浩史*, 菅野江里子, 砂金ひとみ, 廣井照, 太田絵美, 玉井信．チャネルロドプシン2遺伝子を用いた視機能再建の可能性、第34回感覚代行シンポジウム予稿集、27-29.
(2008)
13. 富田浩史, 菅野江里子, 玉井信. 注目の疾患 網膜色素変性 チャネルロドプシン.【網膜硝子体診療update】臨床眼科, 62(11):
336-341. (2008)
14. 富田浩史*, 菅野江里子. 失明者の視覚を取り戻す新しい治療法の開発、医科学応用研究財団研究報告,27, 22-27. (2010)
15. 富田浩史*, 菅野江里子.チャネルロドプシンを用いた視覚再生 （わかりやすい臨床講座）、日本の眼科,
82(12), 1602-07. (2011)
16. 富田浩史*, 菅野江里子, 砂金ひとみ, 村山奈美枝, 小柳恵理, 玉井信.遺伝子治療による視覚再生-緑藻類由来遺伝子の利用-、信学技報（電子情報通信学会,IEICE）, 111(155),
p47-50. (2011)
17. 富田浩史, 菅野江里子.【視覚を用いた脳科学研究】 視覚再生、脳21, 17(4), 479-485. (2014)
18. 富田浩史*, 菅野江里子. 網膜神経節細胞の光活性化を用いた視覚再建の取り組み. 光学, 66(11): 817-823. (2015)
19. 菅野江里子, 冨田浩史. 特集-未来を支えるライフサイエンス~ 視覚障害治療のための可視光に感受性を持つ光活性陽イオンチャネルタンパク質~. 化学工業, 66(11): 817-823. (2015)
20. Tomita
H*. Potential Applications
in Vision Restoration. Wiley Online Library, online (DOI:
10.1002/9780470015902.a0021388.pub2). (2015)
21. 冨田浩史*, 菅野江里子. オプトジェネティクスの視覚への応用-チャネルロドプシン遺伝子の導入による失明者の視覚再建. 光アライアンス, 27(1): 51-55. (2016)
22. 菅野江里子, 富田浩史.特集 網膜色素変性の治療; オプトジェネェティクスを利用した遺伝子治療．眼科, 金原出版,
62(7):p669-675. (2020)
23. 富田浩史*, 菅野江里子.今月の話題 遺伝子治療による視機能再建．臨床眼科, 医学書院, 74(8):p941-948. (2020)
24. 八尾寛、深澤有吾、冨田浩史、五十嵐敬幸. ラットを用いたオプトジェネティクス．LABIO 21, 80, p.5-8, 2020
著書
1.
Ishiguro S,
Tomita H, Watanabe H, Tamai
M, Protection of phosphate-activated glutaminase and suppression of ammonia
elevationby administration of insulin-lime growth factor II in the ischemic rat
retinas, Retinal Degeneration and Regeneration (Kato S, Osborne NN, and Tamai
M, Kugler Publications), p21-22, 1995 ISBN: 978-90-6299-143-3
2.
Tamai M,
Yamada K, Takeda N, Tomita H,
Abe T, Kojima S, Ishiguro S, bFGF transfected iris pigment epithelial cells
rescue photoreceptor cell degeneration in RCS rats, Degenerative Retinal
Diseases (Matthew M. La Vail, Joe G. Hollyfield, Robert E. Andersen, Springer
US), p323-328, 1997, ISBN 978-1-4615-5933-7
3.
Tamai M,
Abe T, Tomita H, Yoshida M,
Kano T, Sato M, Autologous iris pigment epithelial transplantation in patient
with age related macular degeneration, RETINA Current Practice and Future
Trends (Taraprasad Das, PARAS PUBLISHING), p151-161, 1998
4.
Abe T, Tomita H, Ohashi T, Yamada K,
Akaishi K, Yoshida M, Sato M, Tamai M, Characterization of iris pigment
epithelial cell for auto cell transplantation, Retinal Degeneration (Matthew M.
La Vail, Joe G. Hollyfield, Robert E. Anderson, Plenum Publishing Corporation),
p553-558, 1999
5.
小柳光正, 田中徹, 富田浩史, 第22章 バイオエレクトロニクスへの応用, 3次元システムインパッケージと材料技術（監修：須賀唯知, シーエムシー出版）, 246-270, 2007
ISBNコード： 978-4-88231-662-6
6.
Tomita H, Sugano E, Isago H, Murayama N, Tamai M, Gene
Therapy for Retinitis pigmentosa. Gene Therapy, Tools and Potential
Applications (F. Martin), INTECH, p493-510, 2013 ISBN: 978-953-51-1014-9
7.
菅野江里子、冨田浩史, チャネルロドプシンによる遺伝子治療の研究, オプトジェネティクス(光遺伝学)～光操作による行動制御技術～（八尾寛、神取秀樹、小泉 周, ㈱エヌ・ティー・エス出版）, p248-257, 2013 ISBN-13: 978-4864690713
8.
Sugano E, Tomita H, Establishment of gene
therapy using Channelrhodopsin-2 to treat blindness, Optogenetics:
Light-Sensing Proteins and their Applications (Yawo H. Kandori H, Koizumi A,
Springer Japan), p341-352, 2015, ISBN 978-4-431-55516-2
9.
Tomita H, Sugano E, Strategies for restoring vision by
transducing a channelrhodopsin gene into retinal ganglion cells, OPTOGENETICS:
From Neuronal Function to Mapping & Disease Biology (Appasani K, Cambridge
University Book), p382-392, 2016 Online ISBN: 9781107281875
10.
Tomita H,
Sugano E, Optogenetics-mediated gene therapy for retinal diseases, Optogenetics
’Light-Sensing Proteins and Their Applications in Neuroscience and Beyond’,
Yawo H, Kandori H, Koizumi A, Kageyama R, eds. Adv Exp Med Biol,;1293:535-543. 2021
シンポジウム・招待講演
（海外）
1.
Tomita H, Protective
effects of Betaxolol on NMDA induced retinal toxicity. Symposium on Update
Glaucoma Neuroprotection, Ft. Worth, TX. 1999
2.
Tomita H, Gene Therapy for restoring vision, Dept. of
Molecular biology and Genetics, Bogazici University, Istanbul Turkey: Oct. 2010
3.
Tomita H, Channelrhodopsins provide a breakthrough
insight into strategies for curing blindness”, Tohoku University-Hanyang
University Joint Symposium on “Biomedical Engineering in Future Medicine”:
Seoul, Korea: November, 2010
4.
Tomita H, Visual properties of genetically blind rats
transduced with channelrhodopsin-2 gene, The 4th Global Chinese Ophthalmic
Conference, Guangzhou, China: September, 2011
5.
Tomita H, Sugano E, Murayama N, Tabata K, Takahashi M,
Saito T, Tamai M. Channelrhodopsin-2: Application of optogenetic technologies
to vision. World Ophthalmology Congress 2014 JRPS Session: International Forum for
Chorioretinal Dystrophy Part 2. (Tokyo, Tokyo International Forum), 2014.04.05
6.
Tomita H, Sugano E, Murayama N, Tabata K, Takahashi M,
Saito T, Tamai M. Resoration of the majority of the visual spectrum in RCS rats
using AAV-mediated modified volvox channelrhodopsin-1 gene transfer.
International Society for Eye Research. (San Francisco,CA), 2014.07.24
7.
Tomita H, Sugano E, Murayama N, Tabata K, Takahashi M,
Saito T, Tamai M. Gene Therapy for Restoring Vision. The 37th Annual Meeting of
the Japan Neuroscience Society. (Yokohama), 2014.09.12
8.
Tomita H, Sugano E, Tamai M. Use of optogenetic
technologies to retinal gene therapy. International Symposium on Hybrid Organs
of the future. (Osaka, Japan), 2015.03.03
9.
Tomita H, Sugano E, Tamai M. Session: Update on gene
therapy; Restoration of the majority of the visual spectrum by using modified
Volvox channelrhodopsin-1. 19th Retina International World Congress, RIWC 2016
Summay Book: 27. (Taipei, Taiwan), 2016.07.08-10
10. Tomita
H, Sugano E, Tabata K.
Optogenetic gene therapy for retinal degenerative diseases, Japan-France joint
seminar on Regenerative Medicine for Vision Restoration, (Riken, Kobe), 2018.5.29-30
11. Tomita
H, Sugano E, Tabata K.
Possibilities of optogenetic-mediated retinal gene therapies, ProFes seminar in
Takahashi Lab, (Riken, Kobe), 2018.6.7
（国内）
1.
冨田浩史, 石黒誠一, 玉井信. ラット虚血網膜における低親和性NGFレセプターの発現. 日本眼科学会総会,
98: 142. (横浜), 1994.04.21-23
2.
Tomita H, Ishiguro S, Endo S, Tamai M. Protective
effects of Betaxolol on NMDA induced retinal toxicity. Symposium on Update
Glaucoma Neuroprotection, Ft. Worth, TX. 1999.11
3.
冨田浩史, 中沢徹, 菅野江里子, 阿部俊明, 玉井信. 緑内障点眼薬の細胞死保護機構. 仙台シンポジウム. (仙台), 2000.01
4.
冨田浩史. 網膜神経細胞死 網膜疾患,緑内障,そして視神経疾患 網膜虚血障害に対する増殖因子の保護作用. 日本眼科学会総会, 104: 100. (京都), 2000.04.06-08
5.
冨田浩史. 神経保護に対するアプローチ Nipradilolによる神経細胞保護のメカニズム. 日本緑内障学会,
11: 81. (広島), 2001.08.31-09.02
6.
冨田浩史, 菅野江里子, 阿部俊明, 玉井信. 遺伝子導入細胞移植と臨床応用. 日本臨床眼科学会. (盛岡),
2002.09.26-29
7.
冨田浩史. 眼内血管病変の病態研究と治療法の発達 網膜虚血と細胞死. 日本眼科学会総会, 106: 76. (仙台), 2002.05.23-26
8.
冨田浩史, 菅野江里子, 玉井信. 網膜疾患における人工網膜の展望. 日本臨床眼科学会 専門別研究会. (札幌), 2005.10
9.
冨田浩史, 菅野江里子, 砂金ひとみ, 玉井信. チャネルオプシン-2の遺伝子導入による失明治療. 日本再生医療学会 シンポジウム. (名古屋（名古屋国際会議場）),
2008.03.13
10. 冨田浩史, 菅野江里子, 砂金ひとみ, 廣井照, 玉井信. チャネルロドプシン－２による視覚再建. 視覚科学技術コンソーシアム (VSAT), 仙台: 2008.08.17
11. 冨田浩史, 菅野江里子, 砂金ひとみ, 玉井信. チャネルロドプシン2遺伝子を用いた視機能再建の可能性. 第34回（2008年）感覚代行シンポジウム、特別講演: 21-24. (東京（独立行政法人 産業技術総合研究所 臨海副都心センター）), 2008.12.01
12. 冨田浩史, 菅野江里子, 砂金ひとみ, 石塚徹, 八尾寛, 廣井照, 玉井信. 網膜変性疾患の治療に挑む 緑藻類由来遺伝子の導入による視覚再生の現状と課題. 日本眼科学会総会, 113: 70. (東京), 2009.04.16-19
13. 冨田浩史, 菅野江里子, 砂金ひとみ, 廣井照, 王卓, 玉井信. 五感の人工臓器 遺伝子導入による視覚システムの再構築. 人工臓器, 39: S27. (仙台), 2010.11.20
14. 冨田浩史, 菅野江里子, 砂金ひとみ, 王卓, 村山奈美枝, 玉井信. 視覚再生研究の新たな展開. 日本眼科学会総会 イヴニングセミナー. (東京(東京国際フォーラム)), 2011.05.12-15(12)
15. 冨田浩史, 菅野江里子, 砂金ひとみ, 王卓, 村山奈美枝, 玉井信. 遺伝子導入による視覚再建. 日本視覚学会. (東京（工学院大学）), 2011.01.20
16. 冨田浩史, 菅野江里子, 村山奈美枝, 田端喜多子, 高橋麻紀, 斎藤健彦, 西山史朗, 玉井信. 網膜から脳への信号伝達 光による調節、行動との相関、そして視覚の再建 オプトジェネティクスの視覚への応用 失明者の視覚再建を目指して. 日本生理学会, 77: 3. (鹿児島), 2014.03.16-18
17. 冨田浩史, 菅野江里子, 村山奈美枝, 田端希多子, 高橋麻紀, 斎藤 建, 西山史朗, 玉井信. 網膜の再生治療・人工視覚 チャネルロドプシン遺伝子導入による視覚機能再建. 日本眼科学会総会, 118: 175. (東京), 2014.04.02-06（04）
18. 冨田浩史, 菅野江里子, 村山奈美枝, 田端希多子, 高橋麻紀, 斎藤健彦, 西山史朗, 玉井信. みえるしくみ～基礎から臨床応用の可能性まで～. 日本動物学会東北支部. (盛岡（岩手大学）), 2014.07.13
19. 冨田浩史, 菅野江里子, 村山奈美枝, 田端希多子, 高橋麻紀, 斎藤健彦, 西山史朗, 玉井信. オプトジェネティクスの視覚回復への応用. 計測自動制御学会 ライフエンジニアリング部門シンポジウム2014: 20. (金沢大学 鶴間キャンパス), 2014.09.18
20. 冨田浩史, 菅野江里子, 村山奈美枝, 高橋麻紀, 田端喜多子, 西山史朗, 斎藤健彦, 玉井信. オプトジェネティクス(光遺伝学)による生体機能制御 オプトジェネティクスの視覚への応用. 日本レーザー医学会総会, 35: 348. (東京), 2014.11.29-30(30)
21. 冨田浩史. 萎縮型加齢黄斑変性症の治療法開発. メディカルジャパン2016 (第2回日本医療総合展). (大阪), 2017.3.10-13
22. 冨田浩史.オプトジェネティクス技術を用いた視覚再生研究．第10回Retina Research Meeting（東京）,2017.12.09-10
23. 冨田浩史.緑藻由来遺伝子を用いた視覚再生のための遺伝子治療研究．第19回日本ロービジョン学会「ランチョンクルズス」. (旭川), 2018.06.15-16
24. 冨田浩史.視覚再建のための遺伝子治療.第123回日本眼科学会「シンポジウム：網膜変性疾患治療の最前線 基礎研究から臨床応用へ」．（東京）,2019.04.18-21
医療講演会
1.
富田浩史. "緑藻遺伝子を使った治療法への展望." 日本網膜色素変性症協会（ＪＲＰＳ）神奈川支部、医療講演会, 横浜(かながわ県民センター): 6月. 2008.
2.
富田浩史. "視機能再建のための遺伝子治療、チャネルロドプシンによって得られる視覚特性." 日本網膜色素変性症協会（ＪＲＰＳ）宮城県支部 総会・医療講演会, 仙台(仙台福祉プラザ): 7月. 2009
3.
富田浩史. "緑藻由来遺伝子を利用した視覚再生研究." 日本網膜色素変性症協会（ＪＲＰＳ）新潟支部総会・医療講演会, 新潟(新潟市総合福祉会館): 6月. 2009
4.
富田浩史. "緑藻類由来遺伝子を利用した視覚再生の可能性." 日本網膜色素変性症協会（ＪＲＰＳ）近畿2府4県合同 「網膜色素変性症・医療シンポジウム」, 大阪(中央公会堂 大ホール): 2月. 2009.
5.
富田浩史. "視機能再建のための遺伝子治療：現状と課題." 日本網膜色素変性症協会 （ＪＲＰＳ）愛知県支部 総会・医療講演会, 名古屋(なごやＩＭＹホール): 7月. 2010
6.
富田浩史. "視機能再建のための遺伝子治療：現状と課題." 日本網膜色素変性症協会（ＪＲＰＳ）群馬県支部 総会・医療講演会, 前橋市: 6月. 2010
7.
富田浩史. "緑藻類チャネルロドプシン遺伝子を用いた視覚再生研究：現状と課題." 日本網膜色素変性症協会（ＪＲＰＳ）岩手県支部 総会・医療講演会, 盛岡: 9月. 2011.
8.
富田浩史. "緑藻類チャネルロドプシン遺伝子を用いた視覚再生研究：現状と課題." 日本網膜色素変性症協会（ＪＲＰＳ）三重県支部 総会・医療講演会, 松阪: 6月. 2011.
9.
富田浩史. "緑藻類チャネルロドプシン遺伝子を用いた視覚再生研究：現状と課題." 日本網膜色素変性症協会（ＪＲＰＳ）福岡県支部 総会・医療講演会, 福岡: 6月. 2011.
10. 富田浩史. "緑藻類チャネルロドプシン遺伝子を用いた視覚再生研究：現状と課題." 日本網膜色素変性症協会（ＪＲＰＳ）長野県支部 総会・医療講演会, 佐久: 6月. 2013.
11. 富田浩史. "緑藻類チャネルロドプシン遺伝子を用いた視覚再生研究：現状と課題." 日本網膜色素変性症協会（ＪＲＰＳ）石川県支部 総会・医療講演会, 金沢: 6月. 2015.
12. 富田浩史, 菅野江里子, 玉井信. 「遺伝子治療の概要と臨床試験に向けた取り組み」 神戸市難連医療相談会, 神戸: 12月. 2017.
13. 富田浩史, 菅野江里子、田端希多子. 「チャネルロドプシンを用いた網膜再生研究」 ＪＲＰＳ鹿児島県支部医療講演会, 鹿児島: 5月. 2017.
14. 富田浩史, 菅野江里子、田端希多子. 「遺伝子治療-臨床応用へ向けた取り組み」 ＪＲＰＳ新潟県支部医療講演会, 新潟: 5月. 2017.
15. 富田浩史, 菅野江里子、田端希多子. 「遺伝子治療研究の現状」 ＪＲＰＳ長野県支部医療講演会, 佐久平: 6月. 2017.
16. 富田浩史, 菅野江里子、田端希多子. 「遺伝子治療研究の現状」 ＪＲＰＳ岩手県支部医療講演会, 盛岡: 6月. 2017.
17. 富田浩史, 菅野江里子. 「視覚再建のための遺伝子治療－臨床試験に向けて」 ＪＲＰＳ群馬県支部医療講演会, 前橋: 6月. 2019.
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岩手県盛岡市上田4-3-5
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